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International Journal of Vascular Medicine
Volume 2016, Article ID 2191350, 8 pages
Clinical Study

Predictors of Improved Walking after a Supervised Walking Exercise Program in Men and Women with Peripheral Artery Disease

1Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA
2Veterans Affairs Medical Center, Oklahoma City, OK, USA
3Department of Biostatistics and Epidemiology, OUHSC, Oklahoma City, OK, USA

Received 20 July 2016; Accepted 4 December 2016

Academic Editor: Mark Morasch

Copyright © 2016 Andrew W. Gardner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We compared the changes in ambulatory outcomes between men and women with symptomatic peripheral arterial disease (PAD) following completion of a supervised, on-site, treadmill exercise program, and we determined whether exercise training variables and baseline clinical characteristics were predictive of changes in ambulatory outcomes in men and women. Twenty-three men and 25 women completed the supervised exercise program, consisting of intermittent walking to mild-to-moderate claudication pain for three months. Men and women significantly increased claudication onset time (COT) ( and , resp.) and peak walking time (PWT) ( for each group). However, change in PWT was less in women (54%) than in men (77%) (). Neither group significantly changed 6-minute walk distance (6MWD). In women, baseline COT was the only predictor for the change in COT () and the change in PWT (). In men, baseline COT () and obesity () were predictors for the change in COT, and obesity was the only predictor for the change in PWT (). Following a supervised, on-site, treadmill exercise program, women had less improvement in PWT than men, and neither men nor women improved submaximal, overground 6MWD. Furthermore, obese men and patients with lower baseline COT were least responsive to supervised exercise. This trial is registered with, unique identifier: NCT00618670.