Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells

Table 3

Results of bioinformatics analyses on downregulated pathways in HUVECs after TGF1 (10 ng/mL) stimulation.

Pathway analysis	Downregulated gene count	value
Olfactory transduction	405	0.0036241
Apoptosis	86	0.0050919
PI3K-Akt signaling pathway	346	0.006535
mRNA surveillance pathway	91	0.0082309
Ribosome biogenesis in eukaryotes	85	0.0119435
Circadian rhythm	30	0.0140969
Chemical carcinogenesis	80	0.0189201
Ras signaling pathway	227	0.0201366
Melanoma	71	0.0211199
Hypertrophic cardiomyopathy (HCM)	85	0.0284512
Rap1 signaling pathway	213	0.0320182
Estrogen signaling pathway	100	0.0381713
Tight junction	134	0.0382214
Nicotinate and nicotinamide metabolism	28	0.0382726
Drug metabolism-cytochrome P450	68	0.0398014
Serotonergic synapse	114	0.0453301
Neuroactive ligand-receptor interaction	321	0.0459533
Tyrosine metabolism	39	0.0463610