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International Journal of Vascular Medicine
Volume 2017, Article ID 2943467, 5 pages
https://doi.org/10.1155/2017/2943467
Research Article

ABO Gene Polymorphism and Thrombomodulin −33G>A Polymorphism Were Not Risk Factors for Myocardial Infarction in Javanese Men

1Department of Nursing, Faculty of Medicine, Brawijaya University, Malang, Indonesia
2Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia
3Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University, Malang, Indonesia

Correspondence should be addressed to Mohammad Saifur Rohman; moc.oohay@kneoppi

Received 21 February 2017; Revised 30 May 2017; Accepted 6 June 2017; Published 24 July 2017

Academic Editor: Bhagwan Satiani

Copyright © 2017 Mifetika Lukitasari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Genetic factors contribute to about a half of coronary artery diseases. During the last several decades, some studies suggested that non-O blood group and thrombomodulin polymorphism −33G>A are the risk factors of coronary artery disease especially in Asia. There was no prior study in Indonesia regarding this issue. Hence, this study was designed to investigate the correlation of ABO polymorphism and thrombomodulin polymorphism −33G>A with the incidence of acute myocardial infarction (AMI). A total of 192 subjects were enrolled in this case control study. AMI patients were diagnosed based on World Health Organization criteria. Healthy patients were subjects with AMI risk factor without any sign and symptoms of AMI. Patients with diabetes mellitus, cancer, and arrhythmia were excluded from this study. Genotyping for both polymorphisms was performed by PCR RFLP methods. The result of this study suggested that ABO polymorphism and thrombomodulin polymorphism −33G>A were not risk factors of AMI, and , respectively. Furthermore, the analysis to identify the synergy of these polymorphisms failed to prove their correlation with AMI . Conclusively, this study showed that ABO polymorphism and thrombomodulin polymorphism −33G>A were not risk factors of AMI.