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International Journal of Vascular Medicine
Volume 2018, Article ID 9795174, 10 pages
Review Article

Swirling Flow and Wall Shear: Evaluating the BioMimics 3D Helical Centerline Stent for the Femoropopliteal Segment

1Vascular/Endovascular Surgery, Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN, USA
2Department of Angiology, Universitäts-Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany
3Division of Cardiovascular Medicine, Toho University, Ohashi Medical Center, Tokyo, Japan
4Department of Bioengineering, Imperial College, London, UK
5Vascular Center Klinikum Arnsberg, Arnsberg, Germany

Correspondence should be addressed to Timothy M. Sullivan; moc.anilla@navillus.yhtomit

Received 11 November 2017; Accepted 31 December 2017; Published 26 February 2018

Academic Editor: Mark Morasch

Copyright © 2018 Timothy M. Sullivan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The BioMimics 3D self-expanding nitinol stent represents a strategy for femoropopliteal intervention that is alternative or complementary to deployment of drug-coated stents or balloons. Whereas conventional straight stents reduce arterial curvature and disturb blood flow, creating areas of low wall shear, where neointimal hyperplasia predominantly develops, the helical centerline geometry of the BioMimics 3D maintains or imparts arterial curvature, promotes laminar swirling blood flow, and elevates wall shear to protect against atherosclerosis and restenosis. In the multicenter randomized MIMICS trial, treatment of femoropopliteal disease with the BioMimics 3D () significantly improved 2-year primary patency (log-rank test ) versus a control straight stent (), with no cases of clinically driven target lesion revascularization between 12 and 24 months (log-rank test versus controls). In geometric X-ray analysis, the BioMimics stent was significantly more effective in imparting a helical shape even when the arterial segment was moderately to severely calcified. Computational fluid dynamics analysis showed that average wall shear was significantly higher with the helical centerline stent ( Pa versus  Pa, ). A 271-patient multicenter international MIMICS-2 trial and a 500-patient real-world MIMICS-3D registry are underway.