Research Article

Mechanical Occlusion Chemically Assisted Ablation (MOCA) for Saphenous Vein Insufficiency: A Meta-Analysis of a Randomized Trial

Table 1

The characteristics of the included trials.

AuthorVein insufficiencyInterventionControlPostprocedural managementDUS scan findingFollow-up period (percentage lost-to follow-up in groups MOCA and thermal ablation)Adverse event identification

Holewijn et al. 2017 [13]GSVMOCA using ClariVein and polidocanol 3% 2 ml for the first 10-15 cm and 1.5% for the remainder. Pullback rate 7 s/cmRFA using ClosurefastPhlebotomy as indicated, stocking compression for 2 weeksComplete occlusion, partial recanalization >10 cm, complete recanalization1 month (0% & 0%), 12 months (21.4% & 30.1%), 24 months (26.2% & 21.4%)Major: DVT, pulmonary embolism, skin burn, saphenous neuralgia
Minor: phlebitis, induration, hematoma, hyperpigmentation

Vähäaho et al. 2019 [14]GSVMOCA using ClariVein and STS 1.5%. Pullback rate was not definedRFA using Closurefast or EVLA using ELVes 1470-nm diode radial laserPhlebotomy for every patient. Other postprocedural management was not definedComplete occlusion, proximal occlusion, distal occlusion, complete recanalization1 month (0% & 0%), 12 months (18.2% & 6.1%)Major: DVT, nerve injury
Minor: hyperpigmentation, hematoma, phlebitis, lumps

Bootun et al. 2016 [15]GSV, SSVMOCA using ClariVein and STS 2%. Pullback rate was not definedRFA using VenefitPhlebotomy as indicated, stocking compression for 2 weeksComplete occlusion, proximal occlusion, distal occlusion, complete recanalization1 month (13.3% & 55.9%)Major: DVT
Minor: phlebitis

Lane et al. 2016 [16]GSV, SSVMOCA using ClariVein and STS 2%. Pullback rate 7 s/cmRFA using VenefitPhlebotomy as indicated, LMWH administration, stocking compression for 2 weeksComplete occlusion, proximal occlusion, distal occlusion, complete recanalization1 month (16.9% & 26.8%), 6-months (25.3% & 28%)Major: DVT, sensory disturbance
Minor: phlebitis, hyperpigmentation