Segmental Arterial Mediolysis: A Multiguised Vasospastic Arteriopathy with Collateral Mesangial Cell Hyperplasia and Cardiac Toxicity Generated by Norepinephrine and Hyperdense Adrenoceptors Alone or by Crosstalk with Other Pressor Agents

Figure 28

Pulmonary artery segmental arterial mediolysis reparative phase, early. An almost circumferential florid proliferation of young granulation tissue with widely dilated irregularly configured capillaries having an angiomatous appearance (blue arrow) is evident between the adventitia (black arrow) and outer media. The arterial lumen is almost completed filled with a mixed population of endothelial cells, fibroblasts, and myofibroblasts. Hematoxylin & eosin ×100 (adapted from Interventional Cardiology12(3) copyright 2020, online publication).