Review Article

Paleopathology of Human Tuberculosis and the Potential Role of Climate

Table 1

Molecular paleoepidemiology of tuberculosis in various historic populations.

Localization (country)Period/datingMorpho-logically typical cases* (n)Morpho-logically suspective cases* (n)Molecu-larly analyzed cases (n)TB-pos/typical  + suspective cases (n)TB-pos./insuspective cases

Abydos (Egypt)A,B,D3000–2500 BC26/189 132/8 (25.0%)2/5 (40.0%)
Thebes (Egypt)B,D2000–1600 BC112/2114512/13 (92.3%)1/32 (3.1%)
Thebes (Egypt)A,D2000–500 BC330/226563/33 (9.1%)0/23 (0%)
Thebes (Egypt)A,D1600–500 BC518/5194613/23 (56.5%)5/23 (21.7%)
La Celle (France)E500–1200 AD29/105115/11 (45.5%)n.a.
Bacsalmas (Hungary)F;G1600–1700 AD1218/4804612/30 (40.0%)2/16 (12.5%)
Rain/Lech (Germany)C1400–1800 AD1148/2.5475910/59 (17.0%)n.a.
Sulzbürg (Germany)H1550–1750 AD00/252503/25 (12.5%)

*: Typical TB cases and cases with macropathology that might represent mycobacterial disease. For the morphological characteristics of “typical” and “suspective” cases see the text. All data have been taken from own previous publications (some with recalculation in order to render data comparable) ([5]A, [15, 16]B, [17]C, [18]D, [22]E, [23]F, [4]G, [24]H).