Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs

<table>(a) Diferential interference contrast (DIC) microscopy  and (b) transmission electron microscopy  showing the presence of a prominent contractile vacuole (arrows) near the flagellar pocket after treatment of <i>L. amazonensis</i> promastigotes with quinuclidine inhibitors. In the left panel it is possible to observe a rounded and swollen parasite that probably indicates osmotic changes due alterations in the plasma membrane’s permeability. F, flagellum; K, kinetoplast. Bars, <svg height="15.15" id="M48" style="vertical-align:-3.56265pt" version="1.1" viewbox="0 0 20.549999 15.15" width="20.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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Interdisciplinary Perspectives on Infectious Diseases

Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs

Figure 9