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Interdisciplinary Perspectives on Infectious Diseases
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2009
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Article
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Tab 1
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Review Article
Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Table 1
Representative compounds that interfere with sterol synthesis in eukaryotes, fungi and trypanosomatids.
Molecular structure
Name
Class
Mechanism of action
Atorvastatin
Statin
Inhibitor of the HMG-CoA Reductase. Used to treat hyperlipidemia in humans
Alendronate
Bisphosphonate
Inhibitor of the farnesyl diphosphate synthase (FPPS). Used to treat osteoporosis and different bone resorption diseases
BPQ-OH
Quinuclidine
Inhibitor of the squalene synthase (SQS), acting in the cholesterol and ergosterol biosyntheses
Terbinafine
Allylamine
Inhibitor of the squalene epoxidase. Used for a long time to treat fungal infections
Posaconazole
Azole
Inhibitor of the C14
α
-demetilase. One of the triazole used to treat fungal infections
22,26-azasterol
Azasterol
Inhibitor of the Δ
24(25)
-sterol methyltransferase, one enzyme presents exclusively in the ergosterol biosynthesis