Review Article

Update on Babesiosis

Table 2

Diagnosis of babesiosis.

Epidemiology

– Residence in or travel to an area endemic for babesiosis
Ixodes tick bite
– History of recent blood transfusion from a donor living or traveling in a Babesia endemic area

Symptoms

– Fever, fatigue, chills, sweats, headache, myalgia, anorexia, cough, arthralgia, nausea
– Less common: emotional lability and depression, hyperesthesia, sore throat, abdominal pain, conjunctival injection, photophobia, weight loss

Signs on physical examination

– Fever
– Splenomegaly, hepatomegaly, pallor

Common laboratory diagnostic procedures

– Identification of Babesia on Giemsa stained peripheral blood smears
– Amplification of Babesia DNA in blood using polymerase chain reaction
– Four-fold rise in Babesia antibody in acute or convalescent sera or identification of serum Babesia IgM antibody