Interdisciplinary Perspectives on Infectious Diseases / 2009 / Article / Tab 1

Research Article

In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa

Table 1

Etest MIC ( g/mL), Etest Synergy Method, and Time-Kill Assay.

P. aeruginosa
LVX MICTZP MIC

Etest(a)Etest(a)

1 32 256
28 256
332 256
4 32 256
5 324
6 3216
7 324
8 32 64
932 4
10 32 4
11 32 256
12 32 256
13 32 256
14 32 256
15 32 256
16 32 256
17 3216
18 32 256
19 32 256
20 32 256
21 3232
22 32 256
23 3232
24 3216
25 32 256
26 3232
27 32 256
28 328
29 32 256
30 32 256
31 32 256

*Pseudomonas aeruginosa strains with discordant synergy results. (a)Performed in triplicate. (b)Values represent the log10 change in CFU/mL in the time-kill assay after 24 hour exposure to the combination of levofloxacin (LVX) and piperacillin/tazobactam (TZP) compared to the most active drug alone. Negative values indicate a decrease in colony count; positive values indicate an increase in colony count. S: synergy; I: indifference.

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