Comparative histopathology of MHV-A59- and MHV-2-infected mouse spinal cords. Serial cross-sections (5 m thick) from MHV-A59- and MHV-2-infected mouse spinal cord at day 5 post inoculation were stained with H & E (a, b), LCA (c, d), or LFB (e, f). Several inflammatory lesions (a) with infiltrating LCA+ cells (c) were observed in MHV-A59-infected mouse spinal cord (arrows indicate lesion area) whereas in MHV-2-infected mouse spinal cord no parenchymal lesions were observed (b), with only rare LCA+ infiltrates observed near the central canal (d). An adjacent section of MHV-A59-infected spinal cord shows loss of myelin by LFB staining ((e) arrow indicates demyelinated area) whereas normal myelin was observed in MHV-2-infected mouse spinal cord (f). Original magnification of (a–f) is 40x. (adapted from the work of [94]).
