Optic nerve histopathology from MHV-A59-infected and MHV-2-infected mice. Longitudinal sections (5 m thick) of optic nerve from MHV-infected mice are shown. Numerous inflammatory cells are evident in an MHV-A59-infected optic nerve with ON 5 days post inoculation stained by H & E (a) and LCA (b). Optic nerve, 5 days post inoculation, with MHV-2 (d) shows a lack of inflammation, with no LCA staining (e) detected. Viral antigen staining of optic nerve from an MHV-A59-infected mouse (c) shows low-level axonal staining whereas no viral antigen is detected in MHV-2-infected (f) mouse optic nerve. Photographs shown at original magnification x20. (adapted from the work of [94]).
