Comparative CNS pathology of mice infected with isogenic recombinant strains differs in the S gene. Schematic diagram of isogenic recombinant strains RSA59 (S gene denoted in green color) and RSMHV2 (S gene demoted in pink color). Encephalitis (a, b). Haematoxylin- and eosin stained brain sections from the basal fore brain of mice infected with either RSA59 (a) or RSMHV2 (b) at day 5 post infection. Arrows indicate regions of inflammation. Demyelination (c, d): spinal cord sections of mice infected with RSA59 (c) or RSMHV2 (d) at day 30 post infection were stained with Luxol fast blue. The arrows indicate a region of demyelination in (c) and normal myelinated areas of white matter in (d).
