Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease
Figure 4
Representative sections from histopathology of periodontal tissue. Comparative maxillary histology (hematoxylin and eosin) of alveolar bone sections from maxilla of rat infected with P. gingivalis and/or T. denticola at 12 weeks. (a) from sham-infected control rat displaying minimal inflammation, lack of migration of junctional epithelium (JE) and minimal inflammation in the connective tissue (CT); (b) from the P. gingivalis infected rat showing prominent epithelium hyperplasia (EH), migration of JE and increase in number of blood vessels (BV) (indicated by black arrows); (c) from the T. denticola infected rat also exhibits migration of JE and EH; and (d) from the mixed infection with P. gingivalis + T. denticola infected rat demonstrates dense inflammation (DI) (indicated by white arrows) along with migration of JE. JE indicates junctional epithelium, CT connective tissue, EH epithelial hyperplasia, BV blood vessels, DI dense inflammation. All images at 20 magnification.
