Interdisciplinary Perspectives on Infectious Diseases

Research Article

Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease

Table 2

Histometrical analysis of rat periodontal tissue after primary infection with P. gingivalis and T. denticola as mono- and mixed infection.


Histological Parameters	Control	P. gingivalis	T. denticola	P. gingivalis + T. denticola

Apical migration (m)	0 ± 0	75.2 ± 79.5	97.3 ± 59.9	134.6 ± 66.5
Rete ridge elongation (m)	20.8 ± 18.4	68.6 ± 20.2	87 ± 39.1	101.8 ± 41.6
Alveolar bone resorption (m)	205 + 15.9	357.9 + 108.8	425.8 + 134.2	451.2 + 68.4
PMN density (number/0.05 mm 0.05 mm)	2.1 ± 1.4	6.8 ± 2.9	5 ± 2.1	5.1 ± 2
Lymphocytes	3.7 ± 0.9	11.7 ± 3.9	5.5 ± 1.7	6.6 ± 1.6
Blood vessel density (number/0.05 mm 0.05 mm)	2.1 ± 1.0	8.4 ± 1.9	5 ± 2.5	4.3 ± 1.7

Values are presented as mean ± standard deviation (). The distances from the CEJ to the coronal portion of the connective tissue attachment (apical migration of JE). The distances from the CEJ to the apical portion of the rete ridge. The distances from the CEJ to the level of the ABC. Significantly more than sham-infected control group (). Significantly more than sham-infected control group (). Significantly more than sham-infected control group (). Significantly more than P. gingivalis group (). Significantly more than P. gingivalis + T. denticola group (). Significantly more than P. gingivalis + T. denticola group ().