Research Article

COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence

Table 1

Characteristics of full sample by COMT genotype.

COMT genotype
Full sampleVal/ValVal/MetMet/Met
(  192)(  54)(  103)(  35)

Age (years) M (sd)37 (9)35 (9)38 (9)39 (11)
Education (years) M (sd)13 (2)13 (2)13 (2)14 (2)
WRAT4 M (sd)100 (12)99 (11)100 (12)104 (11)
Ethnicity (row )
 Caucasian 71527883v/v v/m, m/m**
 African-American1532711v/v v/m, m/m**
 Hispanic1417166
Executive Functioning Battery
 Wisconsin card sort test T (sd)45 (14)47 (16)44 (13)46 (13)
 Trials part B T (sd)49 (11)51 (12)47 (10)52 (11)
 Halstead category Test T (sd)46 (10)47 (10)44 (10)47 (9)
 Domain deficit score M (sd).55 (.69).56 (.68).62 (.74).35 (.47)
 Executive impairment ( )45465031
Sexual Characteristics/Behavior
 Age at first intercourse (sd)15 (4)14 (4)16 (4)17 (4)v/v m/m*
 Sexual preference (% heterosexual)33353138
 Number partners in past 12 mo Median (IQR)3 (1,10)4 (1, 11)3 (1, 10)2 (1, 5)
 Condom use ( 0% in past 12 mo)72747170
 Insertive anal ( 0% in past 12 mo)62606752
 Receptive anal ( 0% in past 12 mo)58606246
 Oral sex ( 0% in past 12 mo)93949394
 Intoxicated sex ( 0% in past 12 mo)64636661
 Vaginal sex ( 0% in past 12 mo)37353544
DSM-IV Psychiatric Disorder ( lifetime)
 Major depression36363540
 Bipolar I or II4833
 Beck depression inventory M (sd)12 (9)11 (8)13 (10)10 (9)
DSM-IV Substance Dependence ( lifetime)
 Sedative0000
 Cannabis99116
 Opioid0000
 Cocaine77514
 Hallucinogen0000
 Alcohol17152014
Methamphetamine Parameters
 Methamphetamine dependent ( )47375249
 Age at first METH use, yrs M (sd)24 (9)23 (9)25 (8)27 (10)
 Total METH use, yrs M (sd)11 (6)13 (7)11 (6)8 (4)v/v m/m*
 Last use of METH, days Median (IQR)91 (36, 274)122 (45, 731)91 (32, 236)91 (30, 244)
HIV Parameters
 HIV seropositive ( )56705149v/v v/m, m/m*
 HIV RNA, plasma (log copies/mL) M (sd)2.1 (1.9)2.4 (1.7)2.0 (2.0)1.7 (1.9)