COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence

Table 2

Multivariate linear regression coefficients for main, interaction, and stratified effects of executive functioning and COMT in seven sexual risk behavior models.

	Standardized Beta^(a)
	Main Effect		Interaction	Straitfied^(b)
EF measure	EF	COMT	EF × COMT	Val/Val	Val/Met	Met/Met
Sexual Risk Behavior Model	(𝑛= 192)	(𝑛= 192)	(n = 192)	(n = 54)	(n = 103)	(n = 35)
Domain Deficit Score
(1) Partners (# past 12 mo)	0.21^**	0.10	0.50^**	0.03	0.20^**	0.52^***
(2) Condom use (% past 12 mo)	0.03	0.13	0.24	—	—	—
(3) Insertive anal (% past 12 mo)	0.06	0.07	0.50^**	−0.18	0.11	0.18
(4) Receptive anal (% past 12 mo)	0.05	0.05	0.44*	−0.17	0.11	0.13
(5) Oral sex (% past 12 mo)	−0.10	0.07	0.40	—	—	—
(6) Intoxicated sex (% past 12 mo)	0.07	−0.06	0.08	—	—	—
(7) Vaginal sex (% past 12 mo)	−0.03	−0.04	−0.28	—	—	—
Wisconsin Card Sort Test (T-score)
(1) Partners (# past 12 mo)	−0.09	0.08	−0.18	—	—	—
(2) Condom use (% past 12 mo)	−0.10	0.12	−0.25	—	—	—
(3) Insertive anal (% past 12 mo)	0.01	0.07	−0.31	—	—	—
(4) Receptive anal (% past 12 mo)	−0.02	0.04	−0.38	—	—	—
(5) Oral sex (% past 12 mo)	0.20^**	0.09	0.13	—	—	—
(6) Intoxicated sex (% past 12 mo)	−0.04	−0.07	0.32	—	—	—
(7) Vaginal sex (% past 12 mo)	0.04	−0.04	−0.04	—	—	—
Trails B (T-score)
(1) Partners (# past 12 mo)	−0.01	0.08	−0.54	—	—	—
(2) Condom use (% past 12 mo)	−0.07	0.11	0.03	—	—	—
(3) Insertive anal (% past 12 mo)	−0.06	0.06	−0.99^**	0.18	−0.03	–0.38^**
(4) Receptive anal (% past 12 mo)	−0.04	0.03	−0.75*	0.17	−0.06	−0.22
(5) Oral sex (% past 12 mo)	0.10	0.06	−0.68*	0.35^**	0.01	0.01
(6) Intoxicated sex (% past 12 mo)	−0.11	−0.07	0.13	—	—	—
(7) Vaginal sex (% past 12 mo)	0.07	−0.04	0.37	—	—	—
Halstead Category Test (T-score)
(1) Partners (# past 12 mo)	−0.11	0.08	−0.16	—	—	—
(2) Condom use (% past 12 mo)	−0.16^**	0.11	−1.13^**	0.08	–0.19*	–0.49^***
(3) Insertive anal (% past 12 mo)	0.01	0.05	−0.22	—	—	—
(4) Receptive anal (% past 12 mo)	−0.01	0.03	−0.59	—	—	—
(5) Oral sex (% past 12 mo)	0.06	0.06	−0.50	—	—	—
(6) Intoxicated sex (% past 12 mo)	−0.04	−0.06	−0.44	—	—	—
(7) Vaginal sex (% past 12 mo)	−0.05	−0.04	0.25	—	—	—

^(a)all regression models adjusted for METH status, HIV status, age at first intercourse.
^(b)stratified analysis of EF effects by genotype was conducted if a significant (𝑃<.10) interaction was observed.
EF: executive functioning; COMT: catechol-O-methyltransferease (0 = Val/Val; 1 = Val/Met; 2 = Met/Met)
* 𝑃<.10; ^**𝑃<.05, ^***𝑃<.005.