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Interdisciplinary Perspectives on Infectious Diseases
Volume 2014, Article ID 453186, 7 pages
http://dx.doi.org/10.1155/2014/453186
Review Article

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets

Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India

Received 25 October 2013; Revised 2 January 2014; Accepted 7 January 2014; Published 11 March 2014

Academic Editor: Mary E. Marquart

Copyright © 2014 Asrar Alam. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1. List of P. falciparum serine proteases of different classes with their functional domains Genes encoding for P. falciparum serine proteases of chymotrypsin, subtilisin and rhomboid protease clans and their orthologs found in PlasmoDB database (http://www.plasmodb.org/) are listed in the table. Domains present in these proteins were identified by sequence search against Pfam database (http://www.pfam.sanger.ac.uk/). Functions of these proteins if known from published literature are also listed.

Table S2. List of P. falciparum serine proteases with their expression at asexual and sexual stages of the parasite Highest expression of P. falciparum serine proteases at asexual blood stages as determined by microarray analysis and mass spectrometry-based evidence of expression at asexual and sexual stages as deposited in PlasmoDB database (http://www.plasmodb.org/) are presented. Ring, trophozoite and schizont represent asexual blood stage forms.

  1. Supplementary Material