Interdisciplinary Perspectives on Infectious Diseases / 2017 / Article / Tab 3

Research Article

Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia

Table 3

Factors associated with of severe malaria among the study participants, Pawe General Hospital, 2014.

VariablesCategoriesUM: (%)SM: (%)COR (95% CI) valueAOR (95% CI) value

Age (year)<570 (55.1)57 (44.9)3.71 (2.30–5.97)<0.0013.01 (1.83–7.39)<0.001
≥5205 (82.0)45 (18.0)1 (ref)1 (ref)

SexMale160 (73.4)58 (26.6)1.05 (0.67–1.67)0.818
Female115 (72.3)44 (27.7)1 (ref)

Axillary temperature (°c)<37.5113 (74.8)38 (25.2)1 (ref)
37.5–39.4162 (71.7)64 (28.3)1.24 (0.76–2.04)0.2351.03 (0.57–1.84)0.960

AnemiaYes93 (61.2)59 (38.8)2.68 (1.69–4.28)<0.0011.65 (0.93–2.92)0.089
No182 (80.9)43 (19.1)1 (ref)1 (ref)

LeukocytosisYes32 (55.2)26 (44.8)2.6 (1.46–4.63)<0.0013.20 (1.65–6.24)0.001
No243 (76.2)76 (23.8)1 (ref)1 (ref)

LeukopeniaYes33 (84.6)6 (15.4)0.46 (0.19–1.13)0.0900.68 (0.25–1.88)0.462
No242 (71.6)96 (28.4)1 (ref)1 (ref)

ThrombocytopeniaYes154 (72.0)60 (28.0)1.12 (0.71–1.78)0.623
No121 (74.2)42 (25.8)1 (ref)

HCMsNo HCMs70 (93.3)5 (6.7)1 (ref)1 (ref)
0.5–5%143 (77.7)41 (22.3)2.04 (0.63–6.57)0.2343.77 (1.39–10.20)0.009
>5%62 (52.5)56 (47.5)8.31 (3.23–1.36)<0.0016.26 (2.14–14.29)<0.001

HCNsNo HCNs125 (80.6)30 (29.4)1 (ref)1 (ref)
0.5–5%143 (73.7)51 (26.3)1.49 (0.89–2.48)0.1290.79 (0.43–1.46)0.455
>5%7 (25)21 (75)12.5 (4.86–2.12)<0.0017.93 (3.09–16.86)<0.001

Plasmodium speciesP. falciparum191 (67.5)92 (32.5)5.56 (1.63–11.12)0.006
P. vivax50 (87.7)7 (12.3)1.59 (0.38–6.57)0.524
Mixed34 (91.9)3 (8.1)1 (ref)

High parasitemiaYes117 (65.0)63 (35.0)2.18 (1.37–3.47)0.0011.90 (1.13–3.18)0.015
No158 (80.2)39 (19.8)1 (ref)1 (ref)

UM = uncomplicated malaria, SM = severe malaria, = number, COR = crude odds ratio, AOR = adjusted odds ratio, CI = confidence interval, HCMs = hemozoin containing monocytes, HCNs = hemozoin containing neutrophils, ref = reference, and μL = microliter. Mixed refers to P. falciparum and P. vivax coinfection.

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