Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

Table 2

Logistic regression: dental plaque (extent in 10% increments) and the risk of belonging to the LDL concentration range 100–160 mg/dL or >160 mg/dL with reference LDL < 100 mg/dL.

Dependent variable	LDL 100–<160 mg/dL		LDL≥160 mg/dL
	OR (95% CI)	𝑃	OR (95% CI)	𝑃
Plaque, crude	1.03 (1.00–1.06)	0.099	1.08 (1.04–1.12)	<0.001
Model 1*
Plaque	1.00 (1.00–1.04)	0.998	1.03 (0.99–1.07)	0.130
Model 2*
Plaque	1.00 (0.97–1.04)	0.990	1.04 (1.00–1.08)	0.081
Statins	0.37 (0.26–0.54)	<0.001	0.14 (0.09–0.23)	<0.001
Plaque × statin use	0.96 (0.86–1.08)	0.512	0.77 (0.66–0.89)	<0.001

*Model 1: adjusted for age (continuous), sex (male 0, female 1), HbA_1c (continuous), education (10th grade or higher), smoking (pack years), alcohol consumption (g/weekend), and last dental visit (within the last year 0, longer than one year 1).
*Model 2: as model 1 with the additional variables shown.