Research Article
Synthesis and Inhibiting Activity of Some 4-Hydroxycoumarin Derivatives on HIV-1 Protease
Table 3
Anti-HIV-1 activity in cell culture (MT-4 cells) and inhibition of HIV-1 protease activity.
| Compound tested in (MNC-M) | Infection assay MTT- % cell survival | % Inhibition of HIV-1 protease activity |
| (8) (0.001) | 0 | 0 | (9) (0.0001) | 0 | 0 | (10) (0.0001) | 30 | 16 | (11) (0.0001) | 0 | 0 | (7) (0.001) | 78 | 25 | (12) (0.001) | 0 | 0 | Abacavir® (35 × 10−6 M) | 98 | Not tested | Pepstatin® (4.5 × 10−5 M) | Not tested | 100 |
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®reference inhibitors.
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