Synthesis and Inhibiting Activity of Some 4-Hydroxycoumarin Derivatives on HIV-1 Protease

Table 3

Anti-HIV-1 activity in cell culture (MT-4 cells) and inhibition of HIV-1 protease activity.

Compound tested in; (MNC-𝜇M)	Infection assay MTT-; % cell survival	% Inhibition of HIV-1; protease activity
(8) (0.001)	0	0
(9) (0.0001)	0	0
(10) (0.0001)	30	16
(11) (0.0001)	0	0
(7) (0.001)	78	25
(12) (0.001)	0	0
Abacavir^®; (35 × 10^−6 M)	98	Not tested
Pepstatin^®; (4.5 × 10^−5 M)	Not tested	100

^®reference inhibitors.