Resistance of Platelets in Hypercholesterolemia to Inhibition by Activated Coagulation Factor X

<table>Resistance of platelets from patients with hypercholesterolemia to factor Xa<i>. </i>The ADP-induced synthesis of TXA<sub>2</sub> in platelets from normal volunteers (<svg height="10.9125" id="M72" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 42.912498 10.9125" width="42.912498" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="27.969212" y="0">0</tspan>
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</svg>) and patients with hypercholesterolemia (<svg height="10.9125" id="M73" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 42.912498 10.9125" width="42.912498" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="27.969212" y="0">0</tspan>
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</svg>) was determined. Platelet-rich plasma was studied after incubation in Tyrode’s buffer with factor Xa, 1 unit/mL, (dark grey) and without (light grey). NS nonsignificant.</table>

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Figure 3

Figure 3: Resistance of Platelets in Hypercholesterolemia to Inhibition by Activated Coagulation Factor X 