Hepatitis C Virus-Related Lymphomagenesis in a Mouse Model
Figure 3
(a) Serum IL-2, IL-4, IL-10, and IL-12 levels in irf-1+/+ CN2 (Tg+) and irf-1+/+ WT mice measured by ELISA. P values <0.05 were considered significant. (b) Serum IL-2, IL-4, IL-10, and IL-12 levels in irf-1−/− CN2 (Tg+) and irf-1−/− WT mice measured by ELISA. P values are based on the mean cytokine concentrations. (c) Bcl-2 protein levels in the lymph nodes of irf-1+/+ WT and irf-1−/− WT or transgenic (CN2-29) mice on day 0, day 400, and day 500 after administration of AxCANCre. Bcl-2 migrated at 26 kD.
