Hepatitis C Virus-Related Lymphomagenesis in a Mouse Model

Table 1

Synergistic effects of cytokines on Fas-induced apoptosis in irf-1^−/− CN2 mice.

	None	IL-2 + IL-10	IL-2 + IL-12	IL-10 + IL-12
WT mice
Bcl-2 fold increase	−	−	−	−
Annexin V + percentage	****	****	****	****
Caspase-9	**	**	**	**
Caspase-3/7	***	***	***	***
irf-1^−/− mice
Bcl-2 fold increase	−	−	−	−
Annexin V + percentage	***	***	***	***
Caspase-9	**	**	**	**
Caspase-3/7	**	**	**	**
CN2-29 mice
Bcl-2 fold increase	−	+	−	−
Annexin V + percentage	***	**	***	***
Caspase-9	**	*	*	**
Caspase-3/7	**	*	*	*
irf-1^−/− CN2-29 mice
Bcl-2 fold increase	+	+++	++	++
Annexin V + percentage	**	−	*	*
Caspase-9	**	−	*	*
Caspase-3/7	*	−	*	*

Bcl-2: −, less than 2-fold increase; +, more than 2-fold increase; ++, more than 4-fold increase; +++, more than 6-fold increase (in comparison with mock treatment).
Annexin V: −, less than 20% decrease; *, up to 20% decrease; **, up to 40% decrease; ***, up to 60% decrease; ****, more than 60% decrease (in comparison with mock treatment).
Caspase-9: −, less than 10-fold decrease; *, up to 50-fold decrease; **, up to 200-fold decrease; ***, up to 400-fold decrease; ****, more than 400-fold decrease (in comparison with mock treatment).
Caspase-3/7: −, less than 200-fold decrease; *, up to 500-fold decrease; **, up to 1000-fold decrease; ***, more than 1000-fold decrease (in comparison with mock treatment).