Table of Contents
ISRN Endocrinology
Volume 2011 (2011), Article ID 171460, 5 pages
http://dx.doi.org/10.5402/2011/171460
Research Article

Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa

1Department of Internal Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
2Department of Psychiatry, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy

Received 4 April 2011; Accepted 11 May 2011

Academic Editors: M. H. Rasmussen and K. C. Yuen

Copyright © 2011 Guido Carlomagno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Anorexia nervosa is a condition of reduced hemodynamic load, characterized by varying degrees of cardiac remodelling, only in part related to reduced body mass; the mechanism for such variability, as well as its clinical significance, remains unknown. Aim of the study was to assess the possible influence of a great number of clinical, biochemical, and endocrine factors on cardiovascular parameters in restrictive anorexia nervosa. Method. Twenty-five female patients hospitalized for restrictive anorexia nervosa underwent extensive cardiovascular, clinical, and biochemical evaluation. Results. Height-adjusted and cardiac workload-matched left ventricular mass was significantly related to several endocrine parameters, blood pressure, and vasoreactivity. On multivariate analysis, IGF/GH ratio and systolic blood pressure were the only independent predictors of height-adjusted ventricular mass (adj- 𝑅 2 = 0 . 5 8 5 ; 𝑃 = 0 . 0 0 1 ); when matching for cardiac workload, left ventricular mass was independently predicted only by GH and FT3 levels. All effects were independent of patient's weight and BMI. Conclusions. Indices of endocrine impairment seem to be the most relevant determinants of left ventricular hypotrophy in anorectic patients, apparently independent of reduced hemodynamic load and BMI. In particular, IGF/GH ratio and FT3 seem to particularly affect left ventricular mass in this population.