Synthesis, Physiochemical Properties, Photochemical Probe, and Antimicrobial Effects of Novel Norfloxacin Analogues

Table 1

The preliminary screening of antimicrobial activity of the new synthesized compounds.

Compounds/DMF 50 μg/ml disk	Microorganisms/Inhibition zone (mm)
	Gram +ve bacteria^a		Gram − ve bacteria^b		Fungi^c
	B.S.	S.A	E.C.	K.P.	C.A.	A.F.
19	9	8	8	10	10	6
20	18	16	15	14	10	6
21	16	16	14	14	8	6
9	8	8	7	11	9	6
11	13	11	12	13	9	6
23	15	14	15	13	10	6
12	20	19	18	17	10	10
Ny.	6	6	6	10	10	32
Na.	32	30	30	22	6	6

Ny: nystatin, manufactured by Pasteur Lab., Egypt. NS 100 units (100 μg/disk).
Na: nalidixic acid, 30 μg/disk, Bioanalize, Egypt.
^aBacillus Subtilis (B.S.) and Stphylacoccus Aureus (S.A.); ^bEscherichia Coli (E.C.) and Klebsiella Pneumonia (K.P.); ^cCandida Albicans (C.A.) and Aspergillus Funigates (A.F.).