Molecular-Field-Based Three-Dimensional Similarity Studies on Quinoline-Based CNS Active Agents

Table 1

Chemical structures and results in pharmacological testing [16].

Compound no.	X	Y	Ar	Atypical antipsychotic profile
7	H	C=O	6-quinolyl	−*
8	H	CH2	6-quinolyl	−
9	H	C=O	8-quinolyl	−*
10	H	CH2	8-quinolyl	+
11	Cl	C=O	6-quinolyl	−*
12	Cl	CH2	6-quinolyl	−
13	Cl	C=O	8-quinolyl	−*
14	Cl	CH2	8-quinolyl	+

*Show blockade only in apomorphine-induced stereotypy assay indicative of potential to cause extrapyramidal symptoms.