Molecular-Field-Based Three-Dimensional Similarity Studies on Quinoline-Based CNS Active Agents

Table 4

Similarity of test compounds with respect to chlorpromazine and template.

Compd. no.	Similarity		Field similarity		Field score		Vol. similarity		Volume score		Shape similarity		Shape score
	CPZ	Temp	CPZ	Temp	CPZ	Temp	CPZ	Temp	CPZ	Temp	CPZ	Temp	CPZ	Temp
7	0.613	0.603	0.535	0.466	−48.258	−47.987	0.628	0.620	141.826	141.337	0.690	0.740	164.092	185.972
8	0.565	0.579	0.487	0.469	−41.443	−46.261	0.641	0.649	147.210	147.078	0.643	0.689	151.980	172.277
9	0.557	0.575	0.532	0.451	−49.327	−45.631	0.572	0.589	135.325	134.285	0.583	0.699	137.385	174.194
10	0.561	0.576	0.517	0.425	−46.640	−41.811	0.588	0.586	138.021	132.880	0.606	0.728	143.205	181.874
11	0.543	0.596	0.493	0.456	−46.066	−44.811	0.630	0.624	141.855	147.619	0.592	0.736	145.862	191.305
12	0.581	0.582	0.500	0.436	−43.990	−44.166	0.578	0.569	136.276	133.575	0.662	0.728	162.107	188.021
13	0.599	0.635	0.520	0.543	−48.090	−54.255	0.616	0.615	145.549	145.517	0.679	0.726	167.193	188.809
14	0.591	0.618	0.538	0.489	−51.045	−49.919	0.630	0.654	142.092	153.728	0.644	0.748	157.594	193.364
Average	0.576	0.596	0.515	0.467	−46.857	−46.855	0.610	0.613	141.019	142.002	0.637	0.724	153.677	184.477