Table of Contents
ISRN Neurology
Volume 2011, Article ID 192414, 7 pages
Research Article

Is MS Intention Tremor Amplitude Related to Changed Peripheral Reflexes?

1Departments of Biomedical Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
2REVAL, PHL University College Hasselt and BIOMED, University of Hasselt, 3590 Diepenbeek, Belgium
3National MS Center Melsbroek, 1820 Melsbroek, Belgium

Received 7 July 2011; Accepted 26 July 2011

Academic Editors: A. Arboix and A. Mamelak

Copyright © 2011 Peter Feys et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intention tremor is related to lesions in the cerebellum or connected pathways. Intention tremor amplitude decreased after peripheral arm cooling in patients with multiple sclerosis (MS), likely caused by a reduction of muscle spindle afferent inflow, while amplitude increased when muscle spindles were artificially stimulated by tendon vibration. This study investigated the contribution of peripheral reflexes to the generation of MS intention tremor. Tendon reflexes of biceps, triceps, and brachioradialis, muscles were measured, using an electromechanical triggered reflex hammer. MS patients with (n = 17) and without (n = 17) upper limb intention and 18 healthy controls were tested. Latency of brachioradialis, biceps, and triceps tendon reflexes was greater in MS patients with tremor than in healthy controls and MS patients without tremor (except for the triceps reflex). Peak and peak-to-peak amplitude were not different between groups. It is concluded that tendon reflexes were delayed but not enlarged in MS patients with tremor.