Immunomodulators and Immunosuppressants for Japanese Patients with Ulcerative Colitis

Figure 1

Metabolism and transportation of AZA/6-MP and its metabolites. XO: Xanthine oxidase, TPMT: thiopurine S-methyltransferase, HGPRT: hypoxanthine–guanine phosphoribosyl transferase, ITPA: inosine triphosphate pyrophosphatase, IMPDH: inosine monophosphate dehydrogenase, GMPS: guanosine monophosphate synthetase, AZA: azathioprine, 6-MP: 6-mercaptopurine, 6-TUA: 6-thiouric acid, 6-MeMP: 6-methylmercaptopurine, 6-MeMPR: 6-methylmercaptopurine ribonucleotide, 6-TIMP: 6-thioinosine monophosphate, 6-TIDP: 6-thioinosine diphosphate, 6-TITP: 6-thioinosine triphosphate, 6-MeTIMP: 6-methylthioinosine monophosphate, 6-MeTITP: 6-methylthioinosine triphosphate, 6-TXMP: 6-thioxanthosine 50-monophosphate, 6-TGN: 6-thioguanine nucleotide, 6-MeTGN: 6-methylthioguanine nucleotide (redrawn from [7]).