Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks

Figure 1

Effects of DMSO on ACN spontaneous activity and morphology. (a) A gradual decrease in mean spikes per min from 26 units. The sudden augmentation of activity seen during the addition of the test compound is due to mixing of the compound in the bath medium. Horizontal bars represent quasistable states used or quantification of activity changes. (b) Neurons and glia in reference medium (b1) and after 200 min in 4% DMSO (b2). No overt changes in neuronal morphology (phase bright cells) can be identified.