Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks

Figure 4

Subchronic effects of 0.5 mM SO (in 0.5% DMSO) on ACN spontaneous activity and morphology. (a) Mean spike rate per min from 33 units show initial cessation of activity followed by recovery of activity that stabilized to about 40% of the original level at the end of five hours. A complete wash did not lead to any further recovery. (b) and (c) Neurons and glia in reference medium (1) and after 5 hrs in 0.5 mM SO (2). Only minor changes in morphology can be identified.