Research Article

Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks

Figure 7

(a) Influence of bicuculline on network response to styrene oxide titration. Reference activity represents pretreatment with 40 μM bicuculline. The concentration-dependent inhibition of spike activity is significantly less in the presence of bicuculline. (b) Concentration response curve from SO titration experiments under bicuculline ( 𝑛 = 1 0 ). The IC50 shifted from 511 μM (Figure 3) to 1405 μM. The slope is close to the standard curve with a slope of 1, implying competitive antagonism at the GABA receptors.
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