Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks
Figure 7
(a) Influence of bicuculline on network response to styrene oxide titration. Reference activity represents pretreatment with 40 μM bicuculline. The concentration-dependent inhibition of spike activity is significantly less in the presence of bicuculline. (b) Concentration response curve from SO titration experiments under bicuculline (). The IC50 shifted from 511 μM (Figure 3) to 1405 μM. The slope is close to the standard curve with a slope of 1, implying competitive antagonism at the GABA receptors.