Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 208394, 8 pages
http://dx.doi.org/10.5402/2011/208394
Research Article

Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique

Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Mehsana, Gujarat 384001, India

Received 1 April 2011; Accepted 2 May 2011

Academic Editors: C. A. Ventura and C. Zacharis

Copyright © 2011 Shailesh T. Prajapati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design. The ratio of HPMC K4M and PVP K30 ( 𝑋 1 ) and the concentration of melt binder ( 𝑋 2 ) were selected as independent variables, and drug release at 1 hr ( 𝑄 1 ), 4 hr ( 𝑄 4 ), 8 hr ( 𝑄 8 ), diffusion coefficient ( 𝑛 ), and release rate constant ( 𝐾 ) were selected as a dependent variable. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. It was observed that concentration of melt binder had significant effect on 𝑄 1 , 𝑄 4 , 𝑛 , and 𝐾 Binder concentration 25% w/w was found optimum. Optimized formulation ( 𝐹 7 ) showed good similarity with theoretical profile of drug. The 𝑋 2 variable had a significant effect on dependent variables, and the 𝑋 1 variable had no significant effect on dependent variables.