International Scholarly Research Notices / 2011 / Article / Tab 3

Research Article

Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion

Table 3

Combination of Papanicolaou and c-ISH signal patterns to detect CIN1 or CIN2/3.

histology
metaplasia/cervicitisCIN1CIN2/3LSIL-CIN1HSIL-CIN2/3

(1) cytology:NILM300sensitivity69.2% (9/13)76.9% (10/13)
PapLSIL193specificity80.0% (16/20)90.0% (18/20)
ASC-US320PPV69.2% (9/13)83.3% (10/12)
HSIL0210NPV80.0% (16/20)85.7% (18/21)

(2) cytology:NILM000sensitivity88.9% (8/9)66.7% (2/3)
Pap with c-ISHLSIL081specificity66.7% (2/3)100% (9/9)
(EI)ASC-US010PPV88.9% (8/9)100% (2/2)
HSIL002NPV66.7% (2/3)90.0% (9/10)

(3) cytology:NILM000sensitivity50% (1/2)88.9% (8/9)
Pap with c-ISHLSIL011specificity88.9% (8/9)50.0% (1/2)
(I > E)ASC-US000PPV50% (1/2)88.9% (8/9)
HSIL018NPV88.9% (8/9)50.0% (1/2)

Pap, Papacicolaou; NILM, negative for intraepithelial lesion; LSIL, low grade squamous intraepithelial lesion;
ASC-US, atypical squamous cells of undetermined significance; HSIL, high grade squamous intraepithelial lesion;
CIN, cervical intraepithelial neoplasia; PPV, positive predictive value; NPV, negative predictive value
The calculated sensitivity, d/b+d; specificity, a/a+c; PPV, d/c+d; NPV, a/a+b.
LISL-CIN1: a Cytology was NILM, ASC-US, HSIL and histology was metaplasia/cervicitis, CIN2/3 b Cytology was NILM, ASC-US, HSIL and histology was CIN1 c Cytology was LSIL and histology was metaplasia/cervicitis, CIN2/3 d Cytology was LSIL and histology was CIN1. HSIL-CIN2/3; a Cytology was NILM, ASC-US, LSIL and histology was metaplasia/cervicitis, CIN1 b Cytology was NILM, ASC-US, LSIL and histology was CIN2/3 c Cytology was HSIL and histology was metaplasia/cervicitis, CIN1 d Cytology was HSIL and histology was CIN2/3.