“Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors

Table 4

Specific therapeutic effect (STE) and apecific abscopal effect (SAE) in each experimental series and groups of treatment after immunization 3 times with syngeneic IFN_γ secreting cells.

Experimental	Group of	No RT SAE Left	N	Left versus 0		RT : STE right	N	Right versus 0
series	treatment	average ± SE				average ± SE
A	RT
B	RT	0.24 ± 0.06	8	0.01		0.42 ± 0.06	8	<0.0005
C	RT
D	RT	0.30 ± 0.04	7	0.001		0.49 ± 0.04	7	<0.0001
All	RT	0.33 ± 0.04	15	<0.0001		0.46 ± 0.04	15	<0.0001
A	IMU-IFN𝛾
B	IMU-IFN𝛾	−0.17 ± 0.23	8	ns		−0.11 ± 0.16	8	ns
C	IMU-IFN𝛾	0.15 ± 0.05	9	0.02		0.26 ± 0.07	9	ns
D	IMU-IFN𝛾	−0.27± 0.18	1	ns		−0.02 ± 0.29	2	ns
All	IMUIFN𝛾	−0.01 ± 0.09	19	ns		0.09 ± 0.07	19
A	IMU-IFN𝛾 + RT
B	IMU-IFN𝛾 + RT	0.14 ± 0.12	8	0.01		0.26 ± 0.07	8	ns
C	IMU-IFN𝛾 + RT
D	IMU-IFN𝛾 + RT
All	IMU-IFN𝛾 + RT	0.14 ± 0.12	8	0.001		0.26 ± 0.07	8	ns