Preparation of Fluconazole 𝜷-Cyclodextrin Complex Ocuserts: In Vitro and In Vivo Evaluation

Table 2

Physicochemical evaluation of different formulations.

Formulation	Thickness (mm)	Weight uniformity (mg)	Moisture loss (%)	Moisture absorption (%)	Folding endurance	Drug content (%)
F-1	0.16 ± 0.002	17.55 ± 0.107	7.84 ± 0.015	4.78 ± 0.222	74 ± 6.681	89.51 ± 4.568
F-2	0.16 ± 0.001	16.37 ± 0.109	8.54 ± 0.084	5.35 ± 0.155	85 ± 5.847	91.16 ± 6.593
F-3	0.16 ± 0.004	18.35 ± 0.045	9.68 ± 0.045	6.28 ± 0.169	91 ± 6.656	90.26 ± 2.658
F-4	0.16 ± 0.005	15.89 ± 0.028	6.29 ± 0.109	7.84 ± 0.184	68 ± 5.517	85.65 ± 9.657
F-5	0.17 ± 0.003	16.89 ± 0.116	7.57 ± 0.227	8.94 ± 0.167	74 ± 8.594	89.51 ± 7.215
F-6	0.16 ± 0.004	18.48 ± 0.153	8.52 ± 0.024	9.84 ± 0.148	85 ± 6.849	95.21 ± 4.123
F-7	0.16 ± 0.006	15.98 ± 0.117	7.94 ± 0.087	7.51 ± 0.153	85 ± 6.598	88.32 ± 6.597
F-8	0.16 ± 0.005	16.84 ± 0.157	8.54 ± 0.247	8.15 ± 0.048	91 ± 2.955	95.84 ± 5.648
F-9	0.17 ± 0.005	17.97 ± 0.148	9.19 ± 0.028	9.84 ± 0.058	98 ± 5.621	97.26 ± 2.255

All values were expressed as mean ± S.D; number of trials (𝑛)=5.