TY - JOUR A2 - Hull, K. A2 - Frago, L. A2 - Perks, C. M. AU - Deijen, Jan Berend AU - Arwert, Lucia I. AU - Drent, Madeleine L. PY - 2011 DA - 2011/04/03 TI - The GH/IGF-I Axis and Cognitive Changes across a 4-Year Period in Healthy Adults SP - 249421 VL - 2011 AB - After the age of 40, the amount of growth hormone in humans decreases. The reduced activity of the GH-IGF axis may play a role in age-related cognitive impairments. In the present study, mood and cognition of 30 healthy subjects (7 males, 23 females, aged 41–76 yr, mean age 60.9±9.0) were examined twice. At baseline, we determined fasting blood levels of GH and IGF-I. Mood and cognitive status were assessed at baseline and after, on the average, 3 years and 9 months of followup. Working memory performance decreased over the years in the low IGF-group (P=.007), but not the high IGF-I group. Higher levels of GH were related with a better working memory at the second test (r=0.42, P=.01) while higher levels of IGF-I tended to be related with a better working memory (r=0.3, P=.06). The results suggest that higher serum levels of GH and IGF-I preserve the quality of working memory functions over the years. SN - null UR - https://doi.org/10.5402/2011/249421 DO - 10.5402/2011/249421 JF - ISRN Endocrinology PB - International Scholarly Research Network KW - ER -