Research Article

The GH/IGF-I Axis and Cognitive Changes across a 4-Year Period in Healthy Adults

Table 1

Mean mood and memory performance scores (±SD) for the low ( 𝑛 = 1 5 ; mean IGF-I = 13.8 nmol/L) and high ( 𝑛 = 1 5 ; mean IGF-I = 22.5 nmol/L) IGF-I groups. Higher scores for fatigue, mood total, and symbol-digit correspond to worse performance. Higher scores for the other tests correspond to better performance.

Low IGF-IHigh IGF-I
BaselineSession 2BaselineSession 2

Vigor3.25 ± 0.83.48 ± 0.73.39 ± 0.913.23 ± 1.21
Fatigue2.73 ± 0.652.52 ± 0.72.84 ± 0.952.77 ± 1.21
Mood total1.51 ± 0.311.55 ± 0.31.64 ± 0.411.64 ± 0.62
Associate learning trial 14.33 ± 2.093.6 ± 1.963.37 ± 1.73.80 ± 2.21
Associate learning trial 25.0 ± 1.814.67 ± 2.444.8 ± 1.974.53 ± 2.1
Associate learning trial 36.2 ± 2.186.13 ± 1.645.2 ± 2.305.4 ± 1.80
Associate recall6.4 ± 2.25.6 ± 2.775.13 ± 2.105.47 ± 2.39
Digit span forward6.13 ± 1.646.0 ± 1.06.0 ± 1.565.53 ± 1.64
Digit span backward5.47 ± 1.554.27 ± 1.224.93 ± 1.834.67 ± 1.44
Symbol-digit (error)2.47 ± 5.541.6 ± 2.673.36 ± 4.741.45 ± 1.69
WM composite9.8 ± 2.487.87 ± 2.108.67 ± 3.138.47 ± 2.47