Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice
Figure 4
Relative transcript levels of metallothionein-1 (MT-1) in liver and kidney. Mice were orally given NHJD (600 mg/kg), realgar (600 mg/kg), arsenic disulfide (600 mg/kg), sodium arsenite (36 mg/kg), sodium arsenate (88 mg/kg), or distilled water (Control). Tissues were collected 8 h later for total RNA isolation, followed by real-time RT-PCR analysis. Data are mean±SE of 6 mice. Significantly different from controls .
