Research Article

Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice

Table 1

Serum ALT and BUN concentrations in mice treated with NHJD and arsenicals.

GroupsDoseALT (U/L)BUN (mmol/L)

Control0 4 5 . 3 ± 5 . 1 1 1 . 3 ± 0 . 1
NHJD600 mg/kg 6 4 . 3 ± 1 8 . 2 1 3 . 6 ± 2 . 2
Realgar600 mg/kg 5 2 . 8 ± 1 2 . 1 1 1 . 2 ± 2 . 3
Arsenic disulfide600 mg/kg 5 8 . 2 ± 9 . 0 1 1 . 9 ± 1 . 0
Sodium arsenite36 mg/kg 1 0 3 ± 3 1 . 4 1 5 . 6 ± 3 . 0
Sodium arsenate88 mg/kg 9 2 . 5 ± 1 8 . 3 1 4 . 2 ± 1 . 7

Data are mean ± SE, 𝑛 = 6 . 𝑃 < 0 . 0 5 .