Table of Contents
ISRN Pharmaceutics
Volume 2011 (2011), Article ID 260537, 5 pages
http://dx.doi.org/10.5402/2011/260537
Research Article

Water-soluble Fraction of Abelmoschus esculentus L Interacts with Glucose and Metformin Hydrochloride and Alters Their Absorption Kinetics after Coadministration in Rats

1Department of Pharmacy, Southeast University, Dhaka 1213, Bangladesh
2Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh
3Department of Pharmacy, University of Asia Pacific, Dhaka 1209, Bangladesh

Received 8 June 2011; Accepted 10 July 2011

Academic Editors: Y. Murata and T. Pongjanyakul

Copyright © 2011 Hajera Khatun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was done to investigate the effects of water-soluble fraction (WSF) of the fruits of Abelmoschus esculentus L (okra/lady's fingers) on absorption of oral glucose as well as metformin from the gastrointestinal tract in the Long Evans rats. WSF of A. esculentus significantly ( 𝑃 < 0 . 0 5 ) reduced the absorption of glucose as studied in the 24 hrs fasting rats. The effect of WSF of A. esculentus on metformin absorption was studied in alloxan-induced diabetic rats. Significant differences ( 𝑃 < 0 . 0 5 ) were observed in the average blood glucose level from 2 to 24 hours after metformin therapy in presence (33.6 to 34.2 mmol/L) or absence (15.2 to 20.2 mmol/L) of oral WSF of A. esculentus. In both of the experiments, Na-carboxymethylcellulose (CMC) was used as positive control. The results of this study indicate that A. esculentus may improve glycemic control but should not be taken concurrently with metformin hydrochloride in controlling diabetes mellitus.