Water-soluble Fraction of Abelmoschus esculentus L Interacts with Glucose and Metformin Hydrochloride and Alters Their Absorption Kinetics after Coadministration in Rats

Table 2

Blood glucose level (mmol/L) in alloxan-induced diabetic rats after oral administration of metformin, WSF of okra and CMC in alloxan-induced diabetic rats.

Treatment groups	0 hr	2 hrs	4 hrs	8 hrs	12 hrs	24 hrs
NC	4.8±0.04	4.6±0.20	4.7±0.19	4.78±0.02	4.69±0.15	4.9±0.03
DC	33.2±1.02	32.85±0.14	33.7±1.01	34.6±1.35	34.6±0.06	34.2±1.05
MC	32.0±0.40	15.2±0.09	14.9±1.0	17.3±0.04	17.8±1.90	20.2±1.01
DMF	33.5±1.05	33.6±0.95^a	32.2±1.35^a	32.3±2.04^a	32.8±1.02^a	34.2±1.07^a
DMC	33.6±0.19	32.2±0.40^a	25.4±0.1^a	30.0±1.24^a	30.6±0.14^a	33.2±0.09^a

Values are expressed as mean ± SEM of 6 rats/group. NC: normal control; DC: diabetic control; MC: diabetic with metformin only (metformin control); DMF: diabetic with metformin and WSF of A. esculentus; DMC: diabetic with metformin and CMC. ^a𝑃<0.05 compared to MC (ANOVA followed by Dunnett's test).