Table of Contents
ISRN Urology
Volume 2011 (2011), Article ID 261735, 4 pages
http://dx.doi.org/10.5402/2011/261735
Case Report

Giant Retroperitoneal Mucinous Tumor Supportively Diagnosed as a Dedifferentiated Liposarcoma by Fluorescence In Situ Hybridization of MDM2 Gene

1Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Mizuho-ku 467-8601, Nagoya, Japan
2Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Mizuho-ku 467-8601, Nagoya, Japan

Received 10 March 2011; Accepted 27 April 2011

Academic Editors: P.-L. Chang, A. M. El-Assmy, and V. Serretta

Copyright © 2011 Taku Naiki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Surgical resection was performed on a 47-year-old woman for a retroperitoneal mass that weighed 8.5 kg. Histological examination revealed a myxoid sarcomatous tumor. Because diagnosis could not be determined by immunohistochemistry, attention was focused on MDM2 (murine double minute) gene amplification by fluorescence in situ hybridization (FISH) analysis. The tumor was finally determined to be a dedifferentiated liposarcoma. We experienced a case of a giant retroperitoneal dedifferentiated liposarcoma. FISH analysis was useful for the diagnosis and determination of the therapeutic strategy.