| Cluster no. | No. of domains | Function of domains | No. of sequences | Disease implication |
| 1 | 36 | Ubiquitin & kinase motor domain | 106 | Alzheimer's, Von Hippel Lindau, juvenile parkinsonism, spinocerebellar ataxia | 2 | 11 | NTF2, Ubiquitin, CoA dehydrogenase | 11 | Fatty acid disorders | 3 | 20 | Myosin Motor | 135 | Familial hypertrophic cardiomyopathy, neuromuscular disorders | 4 | 9 | Cyclophilin | 3 | Immunosuppression, antiviral activity | 5 | 16 | vWFA & PH, Ubiquitin | 196 | Von Willebrand disease, thrombotic thrombocytopenic purpura (TTP) | 6 | 6 | PH & PTB | 70 | Cardiovascular diseases | 7 | 10 | tRNA synthase | 15 | Aminoacyl tRNA synthetase- charcot-Marie-Tooth disease type 2D, Mobius syndrome, cardiac disorders | 8 | 13 | Ubiquitin & PLAT | 32 | Neurological disorders | 9 | 5 | RNA binding | 1 | Myxoid liposarcoma, sars | 10 | 5 | SIR 2 | 3 | Neurological disorders | 11 | 5 | HMG box | 10 | Alzheimer's disease, heart diseases, diabetes and cancer | 12 | 4 | PI3K | 2 | Cancer, diabetes and respiratory | 13 | 4 | Sm & Sm-like | 8 | Inflammatory bowel disease, Salla disease, diabetes | 14 | 3 | Methyl-CpG and PH | 3 | Cancer, Down syndrome-like Alzheimer's, Wiskott-Aldrich syndrome, B-cell chronic lymphocytic leukemia | 15 | 3 | EVH1 | 1 | Wiskott-Aldrich syndrome | 16 | 3 | CGH & Ntn | 1 | Lysosomal storage disease and progressive neurodegeneration, Farber’s disease, and Alzheimer's Disease | 17 | 3 | Nidogen, thyroglobulin type 1 | 6 | Human gastrointestinal cancer, cancer, acute leukemia, heart diseases |
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