International Scholarly Research Notices / 2011 / Article / Tab 1

Research Article

Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome: Insights of Using Fused Domains in Hypothetical Proteins as Probes

Table 1

Summary of 17 clusters along with their involvement in diseases and major functions. Words in bold indicate neurodegenerative disorders and the role of ubiquitin domains in these disorders.

Cluster no.No. of domainsFunction of domainsNo. of sequencesDisease implication

136Ubiquitin & kinase motor domain106Alzheimer's, Von Hippel Lindau, juvenile parkinsonism, spinocerebellar ataxia
211NTF2, Ubiquitin, CoA dehydrogenase11Fatty acid disorders
320Myosin Motor135Familial hypertrophic cardiomyopathy, neuromuscular disorders
49Cyclophilin3Immunosuppression, antiviral activity
516vWFA & PH, Ubiquitin196Von Willebrand disease, thrombotic thrombocytopenic purpura (TTP)
66PH & PTB70Cardiovascular diseases
710 tRNA synthase15Aminoacyl tRNA synthetase- charcot-Marie-Tooth disease type 2D, Mobius syndrome, cardiac disorders
813Ubiquitin & PLAT32Neurological disorders
95RNA binding1Myxoid liposarcoma, sars
105SIR 23Neurological disorders
115HMG box10Alzheimer's disease, heart diseases, diabetes and cancer
124PI3K2Cancer, diabetes and respiratory
134Sm & Sm-like8Inflammatory bowel disease, Salla disease, diabetes
143Methyl-CpG and PH3Cancer, Down syndrome-like Alzheimer's, Wiskott-Aldrich syndrome, B-cell chronic lymphocytic leukemia
153EVH11Wiskott-Aldrich syndrome
163 CGH & Ntn1Lysosomal storage disease and progressive neurodegeneration, Farber’s disease, and Alzheimer's Disease
173Nidogen, thyroglobulin type 16Human gastrointestinal cancer, cancer, acute leukemia, heart diseases

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