International Scholarly Research Notices / 2011 / Article / Tab 2

Research Article

Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome: Insights of Using Fused Domains in Hypothetical Proteins as Probes

Table 2

A description of genes, domains, and type of inheritance for Parkinson’s disease (source: Nirit Lev and Melamed [1]).

Gene/locus/assignmentDomains presentInheritanceAge of onset

a-Synuclein/SNCA/PARK1 & 4Synuclein/ubiquitin-likeAutosomal dominant/susceptibilityEarly/late
Parkin/PRKN/PARK2Parkin and ubiquitinAutosomal recessive/possible susceptibilityJuvenile/early
Ubiquitin C-terminal hydrolase/UCH-L1/PARK5Peptidase, ubiquitin Autosomal dominant/susceptibilityLate
DJ-1/DJ-1/PARK7GATase/ubiquitin-likeAutosomal recessiveEarly

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