International Scholarly Research Notices / 2011 / Article / Tab 5

Research Article

Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome: Insights of Using Fused Domains in Hypothetical Proteins as Probes

Table 5

Mutational analysis of the hypothetical proteins with ubiquitin domains.

Sl. no.Gi IDMutational positionsFunction as predicted by protein mutant database (PMD)

15912028NilNo change
2 37589137I30VStability is retained.
G35KMelting temperature at pH 3.0 decreases.
3 44662819I30VStability is retained.
G35KMelting temperature at pH 3.0 decreases.
4 57997480G35SMelting temperature at pH 3.0 decreases.
K48RIncrease in morphologic response of cells to canavanine, accumulation of high-molecular-weight ubiquitin conjugates and proteome substrates is observed.
5 12052812R42LUbiquitin adenylate affinity for E1 protein decreases.
G35KMelting temperature at pH 3.0 decreases.
6 10241759R42LUbiquitin adenylate affinity for E1 protein decreases.
G35KMelting temperature at pH 3.0 decreases.

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