Chronic Hypoxia Emerging as One of the Driving Forces behind Gene Expression and Prognosis of Hepatocellular Carcinoma

Figure 3

Selection procedure of 7-gene prognostic hypoxia gene set. We started with the 265 genes that were identified from the microarray experiments with HepG2 cells. After several selection steps, we could identify a 7-gene set (Table 1) with prognostic value from the studies by Wurmbach et al. [75], Lee et al. [50, 51], and Boyault et al. [48]. The prognostic value was subsequently confirmed when we tested this set in the study of Chiang et al. [49].