Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin

Table 6

Kinetic treatment of dissolution data.

	𝐹1	𝐹2	𝐹3	𝐹4	𝐹5	𝐹6	𝐹7	𝐹8	𝐹9
Zero order
𝑏	5.17	5.27	5.42	5.45	5.44	5.89	5.78	4.59	4.42
𝑎	47.48	45.72	43.66	43.52	42.24	37.46	38.33	40.13	40.10
𝑅^2	0.9619	0.9713	0.9716	0.9692	0.9771	0.9844	0.9811	0.9969	0.9941
First order
𝑏	0.030	0.031	0.033	0.033	0.033	0.036	0.035	0.029	0.029
𝑎	1.699	1.686	1.668	1.667	1.657	1.619	1.626	1.637	1.634
𝑅^2	0.9465	0.9554	0.9527	0.9496	0.9604	0.9702	0.9666	0.9874	0.9812
Higuchi
𝑏	24.07	24.42	25.13	25.31	25.14	27.02	26.50	20.73	20.04
𝑎	22.88	20.91	18.09	17.74	16.81	10.41	11.76	19.70	20.54
𝑅^2	0.9832	0.9880	0.9892	0.9877	0.9905	0.9893	0.9873	0.9897	0.9901
Hixon Crowell
𝑏	−0.09	−1.75	−1.80	−1.81	−1.83	−1.96	−1.92	−1.52	−1.47
𝑎	0.973	18.09	18.77	18.82	19.25	20.84	20.55	19.95	19.97
𝑅^2	−0.9525	−0.9713	−0.9715	−0.9691	−0.9775	−0.9843	−0.9810	−0.9969	−0.9940
Korsemeyer and Peppas
𝑛	0.333	0.341	0.361	0.364	0.363	0.396	0.387	0.316	0.313
𝑎	−0.34	−0.355	−0.376	−0.378	−0.385	−0.423	−0.416	−0.395	−0.399
𝑅^2	0.9845	0.9857	0.9885	0.9868	0.9877	0.9802	0.9756	0.9832	0.9859

𝑏 = slope, 𝑎 = intercept, 𝑅² = Square of correlation coefficient, and 𝑛 = diffusion exponent.